As the US, Canada and Mexico kick off negotiations on Wednesday to modernize the North American Free Trade Agreement, the biggest uncertainty is whether a deal can pass President Donald Trump’s “America First” test.

Trump has blamed NAFTA for shuttering US factories and sending US jobs to low-wage Mexico.

The test will be whether negotiators can prove that a new NAFTA agreement can alter that course.

The call from the US-business-community in the run-up to the talks has been “do-no-harm” amid concerns that a new agreement will unravel a complex North American network of manufacturing suppliers built around NAFTA.

Trump pulled the US out of the Trans Pacific Partnership trade pact shortly after taking office in January.

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The American president made trade a centerpiece of his presidential campaign as he promised to reinvigorate the manufacturing sector.

However, he has since backed off other trade threats, including declaring China a currency manipulator and tearing up NAFTA, which he regularly calls a disaster.

US-Canada-Mexico trade has quadrupled since NAFTA took effect in 1994, surpassing one trillion dollars in 2015.

Derek Burney said that in the previous NAFTA talks there was a political commitment from all sides to reach a deal. That is not the case now, he said.

Burney was a former Canadian ambassador to Washington who was involved in the first NAFTA negotiations.  (NAN)